There are thousands of hotels in Rome. You can find hotels in all price ranges: from luxury and boutique hotels to youth hostels. You may choose to stay in a hotel close to the Vatican in the St. Peter- Vatican area or in the historical part of Rome. Alternately you can opt for cheaper accommodation at the area near the Termini station, the main train station of Rome (Closer to the colloseum). Rome has good public transportation and it's easy to get around so you don't have to stay right in the center of things.

Most luxury hotels in Rome are located in the area of the exclusive and fashionable via Vittorio Veneto. Via Veneto is in the historic center and close to the Spanish steps and to villa Borghese.Another option is to stay in the trendy neighborhood of Trastervere that is close to the historical center and not far from the Vatican. This area has plenty of atmosphere and many restaurants and bars. Trastevere is in fact one of Rome's most ancient neighborhoods.

Hotel Alimandi Vaticano
This four star art nouveau style hotel is located right by the walls of the Vatican. The Hotel Alimandi Vaticano faces the entrance to the Vatican Museums. The hotel has 21 bedrooms and 3 luxury suites. The Hotel Alimandi Vaticano offers all modern amenities including high speed internet.
Viale Vaticano 99, Vatican 00165, Rome, Italy

The Westin Excelsior Hotel Rome
The luxurious Westin Excelsior Hotel is located near the beautiful Villa Borghese, on Via Venento. The Westin Excelsior, Rome has been frequented by artists, celebrities, and visiting statesmen. The rooms are decorated in Empire or Biedermeier style. The hotel's amenities include a spa and in-room spa treatments. Some of the places to be visited near the hotel are National Gallery of Ancient Art, the Vittorio Emanuele Monument, the Capitoline Museum.
Via Vittorio Veneto 125, Rome, Italy

Boscolo Palace Roma
The Boscolo Palace, Roma Is a five star luxury Hotel also located in Via Veneto. Its rooms have all the amenities and are designed in an elegant modern Italian style. The hotel has a bar and a restaurant serving delicacies from the Italian kitchen.
Via V. Veneto, 70, Ludovisi, Rome, Italy

Hotel Italia
This two star hotel is located near termini station. The reception is open 24 hours a day. The rooms have private bathrooms, heating, air conditioning, satellite TV, hair dryers and a safe. The hotel offers breakfast from 7:00am-10:00 am. It has an American style bar and provides free WiFi access in all rooms.
Via Venezia, 1800184 ,Rome, Italy

Hotel Trastevere
Situated in a perfect location, by Piazza S. Calisto and right at the center of Trastevere, this reasonably priced hotel has been renovated recently. The Hotel rooms are all equipped with air conditioning, private showers and bathrooms, hair dryiers, Tv sets and telephone lines. Free WiFi is provided.
via Luciano Manara n. 24a/25, Roma, Italy

Legends Hostel
The Legends Hostel is Ideal for backpackers and other budget travelers. Located near termini station, the legends hostel (formerly the Alessandro Legends) offers small dormitories or private accommodation with shared or private bathrooms. All rooms are air conditioned. The hostel offers free linen, 24 hour reception, hot water all day long and free WiFi.
Via Curtatone 12, 00185, Rome, Italy